Research that changes policy

HPTN 084

HPTN 084: Phase III Double Blind Safety and Efficacy Study of Long Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

P1115

A multi-centre phase I/II proof-of-concept clinical trial exploring the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission in neonates. Started in June 2015 at Baylor-Uganda’s Centre of Excellence HIV clinic…

HOPe project

This is a Household-based outreach and patient engagement cross sectional survey targeted to increase TB and HIV case finding among household TB contacts of index TB patients through active contact tracing and use of clinical referral tool…

Odyssey

A ViiV Health care funded randomised trial comparing efficacy and safety of dolutegravir (DTG)-based antiretroviral therapy (ART) versus standard of care (SOC) among HIV-infected children less than18years of age (≥3kg) starting first line…

Combat TB

Community-based initiation of isoniazid preventive therapy (IPT) among household TB contacts in Uganda: A pilot project in Southwestern Uganda.

Co-Hed

Study of Co-medication with HAART and anti-Epileptic Drugs

Breather-Plus

Evaluating the efficacy, safety and acceptability of weekends off DGT-based antiretroviral therapy (ART) and monthly long-acting injectable ART compared to daily DGT-based ART in virologically suppressed HIV-infected children and adolescen…

Smile

Compares safety and antiretroviral effect of current standard ART to once daily intergrase inhibitor (INSTI) administered with darunavir/ritonavir (DRV/r) in HIV-1 infected, virologically suppressed children. This ongoing two arm, phase 2/…

Impaact 2010

This is a phase III randomised open-label clinical trial assessing virologic efficacy and safety of Dolutegravir-containing versus Efavirenz-containing ART regimens in HIV-1 infected pregnant women and their infants. Read more Baylor-Ugand…

Impaact 2009

Assess Feasibility, Acceptability and Safety of Oral Pre-Exposure Prophylaxis for Primary HIV Prevention during Pregnancy and Breast Feeding in Adolescents and Young Women More information about the study can be found here

Mets Study

A cross sectional study of children and adolescent aged 6-19 years living with HIV and receiving ART to determine the prevalence of MetS among children and adolescents living with HIV in Uganda, and to identify risks factors for the develo…

Nod

Novel and Optimized Diagnostics in Pediatric Tuberculosis in Kampala, Uganda

Cohort

Prospective observational cohorts at the Baylor college of medicine children’s foundation – Uganda COE

Differentiated delivery of tuberculosis preventive treatment (Tpt)

Differentiated delivery of tuberculosis preventive treatment (TPT) within existing health facility and community HIV care models to improve TPT uptake and completion among children and adolescents living with HIV in Uganda following the CO…

G11 Sigmar

Strengthening the Administration and Grants Management Capacity of Research directorate at Baylor Uganda through training

Pharmacokinetic and safety studies of new antiretroviral formulations

Expediting UNIVERSAL first and second-line regimens for all children living with HIV in Africa

CoVPN 3008

Multi-Center, Randomized, Efficacy Study of COVID-19 MRNa Vaccine in Regions with SARS-CoV-2 Variants of Concern” in Uganda

Vat 00008 ( Covpn 3005)

A parallel-group, Phase III, multi-stage, modified double-blind, multi-armed study to assess the efficacy, safety, and immunogenicity of two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (monovalent and bivalent) for prevention agains…

Impaact 2026

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum

Impaact 2036

Phase I/II Study of the Safety, Tolerability, Pharmacokinetics, and antiviral activity of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed HIV-Infected

Impaact 2017

Phase 1/11 Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of oral and Long- Acting Injectable Cabotegravir and Long -Acting Injectable Rilpivirine in Virologically Suppressed HIV- Infected Children and Adolescents ‘…

Impaact 2028

Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV

D3 (Penta 21)

A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old

Lata

A randomised open label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of 8 weekly dual long-acting injectable antiretroviral therapy (ART) compared to daily oral dolutegravir/tenofovir-based triple ART in virologic…

Dpart

Pharmacokinetic study of Dihydroartemisinin-Piperaquine (DP) in HIV-infected children on EFV-, LPV/r-, or DTG-based ART and HIV-uninfected children not on ART. All children will be malaria-uninfected.

METs

Prevalence and Risks Associated with Metabolic Syndrome in Children and Adolescents living with HIV in Uganda. A PILOT STUDY

Collaborative African Genomics Network (Cafgen)

Lolipop

Lopinavir/r/ Lamivudine/ Abacavir as an easy to use Paediatric Formulation in a Phase I/II Study (LOLIPOP)

TB Risk Factors

Tuberculosis risk factors and outcomes among children in urban and rural Uganda (TB Risk Factors)

Dedim

Determining the Effectiveness of Dispensing Messages (DEDIM) on Adherence and Viral Suppression among Children with an Unsuppressed Viral Load in Uganda

Up-Art

Uganda Paediatric and Adolescent HIV Cohort on Antiretroviral Therapy Study (UP-ART)

PEPFAR

Accelerating Epidemic Control in Fort Portal Region in the Republic of Uganda under the President’s Emergency Plan for AIDS Relief (PEPFAR)

Mortality Surveillance

All-Cause Mortality Surveillance in Bunyangabu, Kabarole and Kyenjojo districts, Uganda

Rbf

Results Based Financing to achieve HIV/AIDS epidemic control in Fort Portal Region, Uganda (RBF)

Program Outcomes

Program Outcomes in Health Service Delivery at Baylor Uganda Centre Of Excellence and Baylor Supported Health Facilities in Uganda

Gender

GENDER, YOUTH AND SOCIAL INCLUSION ANALYSIS BASELINE ASSESSMENT For the USAID/Local Partner Health Services – Eastern Activity

Baseline Assessment of the Achievements

Baseline Assessment of the Achievements of HIV/AIDS and TB Programming in Eastern Uganda

CAPP-Study

Clinical and pathological phenotypes of paediatric cancers in a sub-Saharan African setting.

Saving Mothers, Giving Life

Reducing maternal mortality in Kabarole, Kyenjojo, and Kamwenge districts.